No one knows exactly how the amyloid beta peptide production and aggregation of cause pathology. Amyloid hypothesis traditionally associated with the accumulation of beta-amyloid peptide neurons in the central event such as degeneration. Aggregated Amyloid fibrils, considered to be the most toxic protein stimulates the calcium ion homeostasis of cells programmed cell death (Apoptosis). It is known that Aβ selectively accumulates, the mitochondria in the cells of Alzheimer's disease, the brain is affected, the use of certain enzymes and inhibits nerve function and glucose.
Various inflammatory processes and also, cytokines play a role in the pathology of Alzheimer's disease. A common sign of inflammation of the tissue and tissue injury diseases must have been hell, or the cursor is in the immune response.
Describes the distribution of the various factors and their receptors on neurons of brain (FDN) derivative instruments for the névrosé expression.
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