Alzheimer Treatment (Diagnosis)

Alzheimer's disease is often clinically diagnosed, the history of the patient, in order to ensure that the members of the family history and the clinical observation functions, neuropsychological and neurolinguistic is based on the presence and absence of alternative criteria. Positron Tomography (pet), the other subtypes of dementia or advanced medical imaging (CT), magnetic resonance imaging (MRI), Computed Tomography and Positron (movement), a single-photon imaging, or brain pathology exclusion. In addition, the conversion of prodromální to expect Alzheimer's disease (mild cognitive impairment).

Evaluation test of intellectual functioning including memory, in the disease progression. Medical organizations in order to facilitate and standardize the diagnostic criteria, the process has created a medical diagnosis. The diagnosis should be confirmed after his death, when the brain is available and suitable equipment are very high.

Alzheimer Treatment (Genetics)

Alzheimer's disease, the majority of the cases are sporadic, meaning that there is no genetic basis, while some genes can have gained by risk factors. On the other hand is about 0.1% of the cases (path) is the dominant autosomno the familiar forms of the world cultural heritage of UNESCO, after 65 years. This form of the disease, early-onset Alzheimer's disease is known as a family.

Alzheimer Treatment (Disease mechanism)

No one knows exactly how the amyloid beta peptide production and aggregation of cause pathology. Amyloid hypothesis traditionally associated with the accumulation of beta-amyloid peptide neurons in the central event such as degeneration. Aggregated Amyloid fibrils, considered to be the most toxic protein stimulates the calcium ion homeostasis of cells programmed cell death (Apoptosis). It is known that Aβ selectively accumulates, the mitochondria in the cells of Alzheimer's disease, the brain is affected, the use of certain enzymes and inhibits nerve function and glucose.

Various inflammatory processes and also, cytokines play a role in the pathology of Alzheimer's disease. A common sign of inflammation of the tissue and tissue injury diseases must have been hell, or the cursor is in the immune response.

Describes the distribution of the various factors and their receptors on neurons of brain (FDN) derivative instruments for the névrosé expression.

Alzheimer Treatment (Biochemistry)

Alzheimer's disease has been identified as a protein misfolding disease (Proteopathy) abnormally folded proteins and beta-definition of accumulation in the brain and Tau. Length of small peptides, amino acids, called amyloid beta, 39 and 43 of disks (also written, and beta or Aβ). Amyloid beta precursor protein transmembrane protein, called amyloid (APP), which is a neural membrane split, such as enter. Implementation is crucial to the growth of nerve cells, survival and compensation mail. "Alzheimer's disease, has been hampered by an unknown process into many small APP to filing of enzymes". "One of these amyloid-beta protein fibres in the fragments, dense deposits outside neurons known as senile plaques these configurations.

Alzheimer Treatment (Neuropathology)

Alzheimer's disease and loss of neurons in the brain circuit of synapses and is characterized by the podkorkovyh in certain areas. This is a consequence of the gross loss in the areas concerned, including spyware that atrophy of the time, and the front lobes of cortex may limbic lobe degeneration of the nervous system and the structure of the cortex. MRI and pet study documented in specific areas of the brain, the cognitive impairment and people with mild Alzheimer's disease varies considerably, EA and elderly people in good health like photos.